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Loss of heterozygosity on the X chromosome in human breast cancer

✍ Scribed by Marie-Louise Loupart; Susan Adams; John A. L. Armour; Rosemary Walker; William Brammar; Jennifer Varley

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
922 KB
Volume
13
Category
Article
ISSN
1045-2257

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✦ Synopsis

The analysis of loss of heterozygosity (LOH) in tumours can be a powerful tool for mapping the sites of tumour suppressor genes in the human genome. A panel of breast cancer patients was assembled as pairs of tumour and lymphocyte DNA samples and LOH studies carried out by Southern hybridisation with polymorphic loci mapping t o the X chromosome with appropriate controls. Deletion mapping revealed a high frequency of small regionalised deletions, defining at least three independent regions, one of which is particularly well mapped t o a 500 kb stretch of DNA in the distal portion of the pseudoautosomal region of Xp. A second region has been identified within the pseudoautosomal region close to the pseudoautosomal boundary, and there is a third discrete site of loss on distal Xq. Perturbations of sequences at these regions represent independent events in a number of patients. This study represents the first detailed analysis of LOH on the X chromosome in human breast tumours, the results of which indicate that at least three regions of this chromosome are involved in the disease.

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