Immunohistochemical expression of thymidylate synthase as predictor of response to capecitabine in patients with advanced colorectal adenocarcinoma
β Scribed by J. LINDEBJERG; J. NEDERBY NIELSEN; L. DAMKIER HOEFFDING; A. JAKOBSEN
- Book ID
- 109343404
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 162 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0365-5555
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## Abstract Thymidylate synthase (TS) is the primary target of 5βfluorouracil (5βFU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5βFUβbased chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has
## Abstract ## Purpose To identify if thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and ratio TP/DPD levels in tumor tissues are potential predictive factors for response to combined preoperative chemoradiation with capecitabine, in patients with locally advanced rectal canc