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Liver-only metastatic colorectal cancer patients and thymidylate synthase polymorphisms for predicting response to 5-fluorouracil-based chemotherapy

✍ Scribed by Graziano, F; Ruzzo, A; Loupakis, F; Santini, D; Catalano, V; Canestrari, E; Maltese, P; Bisonni, R; Fornaro, L; Baldi, G

Book ID
109999649
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
122 KB
Volume
99
Category
Article
ISSN
0007-0920

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has