Single nucleotide polymorphism in the 5′
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Eugenio Marcuello; Albert Altés; Elisabeth del Rio; Angeles César; Anna Menoyo;
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Article
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2004
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John Wiley and Sons
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French
⚖ 84 KB
## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has