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Relationship of polymorphism of the tandem repeat sequence in the thymidylate synthase gene and the survival of stage III colorectal cancer patients receiving adjuvant 5-flurouracil-based chemotherapy

✍ Scribed by Chi-Min Park; Woo Yong Lee; Ho-Kyung Chun; Yong Beom Cho; Hae Ran Yun; Jin Seok Heo; Seong Hyeon Yun; Hee Cheol Kim


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
125 KB
Volume
101
Category
Article
ISSN
0022-4790

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Single nucleotide polymorphism in the 5′
✍ Eugenio Marcuello; Albert Altés; Elisabeth del Rio; Angeles César; Anna Menoyo; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 84 KB

## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has