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Protracted continuous infusion of 5-fluorouracil and low-dose leucovorin in patients with metastatic colorectal cancer resistant to 5-fluorouracil bolus-based chemotherapy: a phase II study

✍ Scribed by Alfredo Falcone; Giacomo Allegrini; Monica Lencioni; Elisabetta Pfanner; Isa Brunetti; Caudia Cianci; Costanza Galli; Gianluca Masi; Andrea Antonuzzo; Pierfranco Conte


Publisher
Springer
Year
1999
Tongue
English
Weight
72 KB
Volume
44
Category
Article
ISSN
0344-5704

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Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer