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Phase I study of gefitinib, irinotecan, 5-fluorouracil and leucovorin in patients with metastatic colorectal cancer

✍ Scribed by Jeffrey A. Meyerhardt; Jeffrey W. Clark; Jeffrey G. Supko; Joseph P. Eder; Shuji Ogino; Clinton F. Stewart; Ferdinando D’Amato; Janet Dancey; Peter C. Enzinger; Andrew X. Zhu; David P. Ryan; Craig C. Earle; Robert J. Mayer; Ann Michelini; Kate Kinsella; Charles S. Fuchs


Publisher
Springer
Year
2007
Tongue
English
Weight
329 KB
Volume
60
Category
Article
ISSN
0344-5704

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## Background: Colorectal carcinoma is the third leading cause of cancer-related death. the primary treatment for patients with metastatic colorectal carcinoma is systemic chemotherapy with 5-fluorouracil (5-fu) and leucovorin (lv), a biomodulator of 5-fu that has been shown to enhance its activity