Expression of thymidylate synthase determines the response of gastric cancer patients undergoing gastrectomy to 5-fluorouracil-based adjuvant chemotherapy
β Scribed by Chun-Nan Yeh; Shih-Ming Jung; Tsung-Wen Chen; Tsann-Long Hwang; Yi-Yin Jan; Miin-Fu Chen
- Book ID
- 106108447
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 277 KB
- Volume
- 395
- Category
- Article
- ISSN
- 1435-2451
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## Background: In the past 4 years, the weekly 24-hour infusion of high dose 5-fluorouracil (5-fu) and leucovorin in the treatment of patients with advanced gastric carcinoma has been prospectively studied at the authors' institution. this has enabled them to explore the possibility that the level
## Abstract Thymidylate synthase (TS) is the primary target of 5βfluorouracil (5βFU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5βFUβbased chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has