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Thymidylate Synthase Gene Polymorphism Affects the Response to Preoperative 5-Fluorouracil Chemoradiation Therapy in Patients With Rectal Cancer

✍ Scribed by Hyuk Hur; Jeonghyun Kang; Nam Kyu Kim; Byung Soh Min; Kang Young Lee; Sang Joon Shin; Ki Chang Keum; Junjeong Choi; Hoguen Kim; Sung Ho Choi; Mi-Young Lee


Book ID
118455202
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
560 KB
Volume
81
Category
Article
ISSN
0360-3016

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has