## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30
✦ LIBER ✦
Thymidylate synthase germline polymorphisms in rectal cancer patients treated with neoadjuvant chemoradiotherapy based on 5-fluorouracil
✍ Scribed by David Páez; Laia Paré; Albert Altés; Francesc Josep Sancho-Poch; Lourdes Petriz; Jordi Garriga; Josep Maria Monill; Juliana Salazar; Elisabeth del Rio; Agustí Barnadas; Eugenio Marcuello; Montserrat Baiget
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 330 KB
- Volume
- 136
- Category
- Article
- ISSN
- 1432-1335
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The prognostic significance of thymidyla
✍
Søren Astrup Jensen; Ben Vainer; Jens Benn Sørensen
📂
Article
📅
2006
🏛
John Wiley and Sons
🌐
French
⚖ 350 KB
Single nucleotide polymorphism in the 5′
✍
Eugenio Marcuello; Albert Altés; Elisabeth del Rio; Angeles César; Anna Menoyo;
📂
Article
📅
2004
🏛
John Wiley and Sons
🌐
French
⚖ 84 KB
👁 1 views
## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has