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Thymidylate synthase polymorphism in sporadic colorectal and gastric cancer in Tunisian population: a predictive role in 5-fluorouracil based chemotherapy treatment

✍ Scribed by O. Baroudi; T. Baroudi; I. Omrane; A. Moussa; A. Mezlini; H. Ayari; S. Guermazi; A. Bahloul; H. Bouzaienne; N. Uhrhammer; Y. J. Bignon; A. B. El-gaaied; K. Bougatef

Book ID
121824957
Publisher
Springer US
Year
2014
Tongue
English
Weight
245 KB
Volume
31
Category
Article
ISSN
1357-0560

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has