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Dihydropyrimidine Dehydrogenase and Thymidylate Synthase Polymorphisms and Their Association with 5-Fluorouracil/Leucovorin Chemotherapy in Colorectal Cancer

✍ Scribed by Andrew X. Zhu; Thomas A. Puchalski; Vincent P. Stanton Jr; David P. Ryan; Jeffrey W. Clark; Steven Nesbitt; Olga Charlat; Patrick Kelly; Elaine Kreconus; Bruce A. Chabner; Jeffrey G. Supko

Book ID
119934929
Publisher
CIG Media Group, LP.
Year
2004
Tongue
English
Weight
286 KB
Volume
3
Category
Article
ISSN
1533-0028

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## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30