## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30
✦ LIBER ✦
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer
✍ Scribed by Robert Mauritz; Cees J. van Groeningen; Kees Smid; Gerrit Jansen; Herbert M. Pinedo; Godefridus J. Peters
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- French
- Weight
- 86 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0020-7136
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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has