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Dihydropyrimidine dehydrogenase and thymidylate synthase in relation to 5-fluorouracil sensitivity of breast cancer

โœ Scribed by T. Inomoto; T. Kitai; M. Ukikusa; K. Ino; H. Higashiyama; A. Arimoto; Y. Nakajima; T. Hanafusa; H. Awane; H. Kobayashi


Book ID
117667745
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
141 KB
Volume
35
Category
Article
ISSN
0959-8049

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Thymidylate synthase and dihydropyrimidi
โœ Wataru Ichikawa; Takehiro Takahashi; Kenichi Suto; Zenro Nihei; Yoshinori Shirot ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 269 KB

## Abstract Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are important enzymes of DNA __de novo__ synthesis and the salvage pathway in cancer cells, respectively. Intratumoral TS and DPD gene expressions were evaluated to determine the correlation between the expression of th