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Variants in the Dihydropyrimidine Dehydrogenase, Methylenetetrahydrofolate Reductase and Thymidylate Synthase Genes Predict Early Toxicity of 5-Fluorouracil in Colorectal Cancer Patients

✍ Scribed by Kristensen, M.; Pedersen, P.; Melsen, G.; Ellehauge, J.; Mejer, J.


Book ID
121346156
Publisher
SAGE Publications
Year
2010
Tongue
English
Weight
182 KB
Volume
38
Category
Article
ISSN
0300-0605

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## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30