The prognostic significance of thymidyla
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SΓΈren Astrup Jensen; Ben Vainer; Jens Benn SΓΈrensen
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Article
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2006
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John Wiley and Sons
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French
β 350 KB
## Abstract Cytotoxic effect of 5βfluorouracil 5βFU is mediated through inhibition of thymidylate synthase (TS), and 5βFU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5βFU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30