Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative activity and 5-fluorouracil sensitivity in colorectal carcinoma
✍ Scribed by R. Fujii; A. Seshimo; S. Kameoka
- Book ID
- 106285618
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 254 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1341-9625
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## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30
## Abstract We have previously reported that activation of the G protein coupled calcium‐sensing receptor (CaSR) by extracellular Ca^2+^ down‐modulates the expression of thymidylate synthase (TS) and survivin and promotes sensitivity to fluorouracil in human colon carcinoma cells. Here, we report f
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