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Thymidylate synthase polymorphism and survival of colorectal cancer patients treated with 5-fluorouracil

✍ Scribed by Ulrich, C M; Potter, J D


Book ID
109997208
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
41 KB
Volume
86
Category
Article
ISSN
0007-0920

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## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30