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Thymidylate synthase expression and ts gene polymorphism in colorectal cancer: implications on therapeutic response to 5-FU

✍ Scribed by Varzim, G.; Santos, L.; Salgueiro, N.; Veiga, I.; Fragoso, M.; Sousa, O.; Tavares, A.; Lopes, C.; Sanches, E.; Guimarães dos Santos, J.

Book ID: 122566181
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 158 KB
Volume: 37
Category: Article
ISSN: 0959-8049
DOI: 10.1016/S0959-8049(01)81591-4

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has