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116 Thymidylate Synthase (TS) Expression Predicts the Response to 5-FU Based Adjuvant Therapy in Pancreatic Cancer

✍ Scribed by Hu, Y

Book ID: 122994254
Publisher: Springer-Verlag
Year: 2003
Tongue: English
Weight: 56 KB
Volume: 7
Category: Article
ISSN: 1091-255X
DOI: 10.1016/S1091-255X(02)00318-9

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has