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Peptide modification by introduction ofα-trifluoromethyl substituted amino acids

✍ Scribed by N. Sewald; W. Hollweck; K. Mütze; C. Schierlinger; L. C. Seymour; K. Gaa; K. Burger; B. Koksch; H. D. Jakubke


Book ID
104949837
Publisher
Springer
Year
1995
Tongue
English
Weight
433 KB
Volume
8
Category
Article
ISSN
0939-4451

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📜 SIMILAR VOLUMES


Peptide modification by incorporation of
✍ Klaus Burger; Norbert Sewald; Christian Schierlinger; Kerstin Mütze; Liza C. Sey 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 23 KB

a-Trifluoromethyl a-amino acids are potentially intaresting candidates for modification of biological active peptides. We report on new strategies for asymmetric synthesis of a-trifluoromethyl substituted a-amino acids. Approaches to amino group protection and carboxylic group activation are present

Incorporation of α-trifluoromethyl subst
✍ K. Burger; K. Mütze; W. Hollweck; B. Koksch 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 694 KB

Methodology for incorporation of cz-tfifluoromethyl substituted amino acids into the Cand N-terminal position of peptides and pcptide mimcfics via multicomponcnt reactions of the Passefini and Ugi type is dcscfibed.