Peptide modification by introduction ofα-trifluoromethyl substituted amino acids
✍ Scribed by N. Sewald; W. Hollweck; K. Mütze; C. Schierlinger; L. C. Seymour; K. Gaa; K. Burger; B. Koksch; H. D. Jakubke
- Book ID
- 104949837
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 433 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0939-4451
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📜 SIMILAR VOLUMES
a-Trifluoromethyl a-amino acids are potentially intaresting candidates for modification of biological active peptides. We report on new strategies for asymmetric synthesis of a-trifluoromethyl substituted a-amino acids. Approaches to amino group protection and carboxylic group activation are present
Methodology for incorporation of cz-tfifluoromethyl substituted amino acids into the Cand N-terminal position of peptides and pcptide mimcfics via multicomponcnt reactions of the Passefini and Ugi type is dcscfibed.