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ChemInform Abstract: Peptide Modification by Introduction of α-Trifluoromethyl Substituted Amino Acids

✍ Scribed by N. SEWALD; W. HOLLWECK; K. MUETZE; C. SCHIERLINGER; L. C. SYEMOUR; G. GAA; K. BURGER; B. KOKSCH; H. D. JAKUBKE

Book ID
112024535
Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
26
Category
Article
ISSN
0931-7597

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Peptide modification by incorporation of
Peptide modification by incorporation of α-trifluoromethyl substituted α-amino acids
✍ Klaus Burger; Norbert Sewald; Christian Schierlinger; Kerstin Mütze; Liza C. Sey 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 23 KB

a-Trifluoromethyl a-amino acids are potentially intaresting candidates for modification of biological active peptides. We report on new strategies for asymmetric synthesis of a-trifluoromethyl substituted a-amino acids. Approaches to amino group protection and carboxylic group activation are present