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Synthetic strategies to α-trifluoromethyl and α-difluoromethyl substituted α-amino acids

✍ Scribed by Smits, René; Cadicamo, Cosimo Damiano; Burger, Klaus; Koksch, Beate


Book ID
115536993
Publisher
Royal Society of Chemistry
Year
2008
Tongue
English
Weight
832 KB
Volume
37
Category
Article
ISSN
0306-0012

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✍ Klaus Burger; Norbert Sewald; Christian Schierlinger; Kerstin Mütze; Liza C. Sey 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 23 KB

a-Trifluoromethyl a-amino acids are potentially intaresting candidates for modification of biological active peptides. We report on new strategies for asymmetric synthesis of a-trifluoromethyl substituted a-amino acids. Approaches to amino group protection and carboxylic group activation are present