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On the total synthesis of (S)-methanophenazine and the formal synthesis of (R)-methanophenazine from a common precursor

✍ Scribed by Uwe Beifuss; Mario Tietze

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
79 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

Methanophenazine is a new cofactor from methanogenic archaea. (S)-Methanophenazine has been synthesized from three building blocks, i.e. 2-hydroxy-phenazine, ethyl (R)-3-methylglutarate and (E,E)farnesyl acetone; a stereodivergent approach from ethyl (R)-3-methylglutarate warrants the formal synthesis of (R)-methanophenazine.

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