The Formal Total Synthesis of Epothilone
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Markus Kalesse; Monika Quitschalle; Eckhard Claus; Kai Gerlach; Axel Pahl; Hartm
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Article
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1999
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John Wiley and Sons
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English
β 347 KB
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The formal total synthesis of epothilone A is described. The 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reactio