𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Nucleosides and Nucleotides, Part 144 Synthesis and Antiviral Activity of 5-Substituted (2′S)-2′-Deoxy-2′-C-Methylcytidines and -uridines[1]

✍ Scribed by Hirokazu Awano; Satoshi Shuto; Takanori Miyashita; Noriyuki Ashida; Haruhiko Machida; Toshihiko Kira; Shiro Shigeta; Akira Matsuda

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
722 KB
Volume
329
Category
Article
ISSN
0365-6233

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Nucleotides. Part. XXXII. Synthesis of 2
Nucleotides. Part. XXXII. Synthesis of 2′–5′ Connected oligonucleotides. Prodrugs for antiviral and antitumoral nucleosides
✍ Piet Herdewijn; Ramamurthy Charubala; Erik De Clercq; Wolfgang Pfleiderer 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 German ⚖ 703 KB

The cytotoxically and antivirally active compounds bvU, (l), flu, (4). acyclovir (7), and A, (12) have chemically been combined with the appropriately protected (2-5')diadenylate 20 by the phosphotriester approach to give the 2'-5' oligonucleotide trimers 21-24. The deprotection of the various block

Nucleosides and Nucleotides. Part 13. Sy
Nucleosides and Nucleotides. Part 13. Synthesis and spectral properties of 1- (3′-O-Phosphoryl-2′-deoxy-β -D-ribofuranosyl)-2(1H)-pyridone-(3′-5′)-1-(2′-deoxy-β-D-ribofuranosyl)-2 (1H)-pyridone
✍ Nico Cerletti; Urs Séquin; Christoph Tamm; Werner Zürcher 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 German ⚖ 444 KB 👁 1 views

## Abstract The dinucleoside phosphate __Π__~d~p__Π__~d~ (**4**) was synthesized from the monomers 1‐(5′‐__O__‐monomethoxytrityl ‐ 2′ ‐ deoxy ‐ β ‐ D ‐ ribofuranosyl) ‐ 2 (1 __H__) ‐ pyridone ((MeOTr) __Π__~d~, **2**) and 1‐(5′‐__O__‐phosphoryl‐3′‐__O__‐acetyl‐2′‐deoxy‐β‐D‐ribofuranosyl)‐(1__H__)‐p

A general synthesis of 2′-deoxy-2′-[18F]
A general synthesis of 2′-deoxy-2′-[18F]fluoro-1-β-D-arabinofuranosyluracil and its 5-substituted nucleosides
✍ Mian M. Alauddin; Peter S. Conti; John D. Fissekis 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 77 KB 👁 1 views

## Abstract Several 2′‐deoxy‐2′‐[^18^F]fluoro‐1‐__β__‐D‐arabinofuranosyluracil derivatives have been synthesized. Coupling of 1‐bromo‐2‐deoxy‐2‐[^18^F]fluoro‐3,5‐di‐O‐benzoyl‐__α__‐D‐arabinofuranose **2** with protected uracil derivatives **3a–e** followed by hydrolysis and high‐performance liquid

Synthesis and antiviral activity of 2-de
Synthesis and antiviral activity of 2-deoxy-1,5-anhydro-D-mannitol nucleosides containing a pyrimidine base moiety
✍ María-Jesús Pérez-Pérez; Erik De Clercq; Piet Herdewijn 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 210 KB

Nucleoside analogues containing a 2-deoxy-l,5-anhydro-D-mannitol and a pyrimidine base moiety were synthesized starting from D-glucose via a nucleophilie opening of an epoxide with the heterocyelic base and an inversion of configuration at the 3'-position. Study of the conformation of these molecule

ChemInform Abstract: Nucleosides and Nuc
ChemInform Abstract: Nucleosides and Nucleotides. Part 155. Synthesis, Antitumor Effects, and Possible Enzymatic Activation Mechanism of 5′-Phosphatidyl-2′- deoxy-2′-methylenecytidine (DMDC).
✍ S. SHUTO; H. AWANO; A. FUJII; K. YAMAGAMI; A. MATSUDA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB

Nucleosides and Nucleotides. Part 155. Synthesis, Antitumor Effects, and Possible Enzymatic Activation Mechanism of 5'-Phosphatidyl-2'deoxy-2'-methylenecytidine (DMDC). -The title compounds (III) are synthesized using an enzyme-catalyzed transphosphatidylation. They show remarkable antileukemic and