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ChemInform Abstract: Enzymatic Synthesis and Antiviral Activity of 2′-Deoxy-2′-fluoro- ribavirin.

✍ Scribed by M. J. SLATER; C. GOWRIE; G. A. FREEMAN; S. A. SHORT

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199715213

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Chemoenzymatic Synthesis of Fluorinated Carbohydrates: 2-Deoxy-2-fluoro-D-glucose and 5-Deoxy-5-fluoro-manno-y-lactol. -The title compounds (III) and (VI) are prepared from the diols (I), which are obtained by microbial oxidation of the corresponding halobenzenes with E. coli JM109. Oxidative cleav