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ChemInform Abstract: Nucleosides and Nucleotides. Part 155. Synthesis, Antitumor Effects, and Possible Enzymatic Activation Mechanism of 5′-Phosphatidyl-2′- deoxy-2′-methylenecytidine (DMDC).

✍ Scribed by S. SHUTO; H. AWANO; A. FUJII; K. YAMAGAMI; A. MATSUDA

Publisher: John Wiley and Sons
Year: 2010
Weight: 29 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199703274

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✦ Synopsis

Nucleosides and Nucleotides. Part 155. Synthesis, Antitumor Effects, and Possible Enzymatic Activation Mechanism of 5'-Phosphatidyl-2'deoxy-2'-methylenecytidine (DMDC).

-The title compounds (III) are synthesized using an enzyme-catalyzed transphosphatidylation. They show remarkable antileukemic and antitumor activities. -(SHUTO, S.; AWANO,

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