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Nucleosides and nucleotides. 155. synthesis, antitumor effects, and possible enzymatic activation mechanism of 5′-phosphatidyl-2′-deoxy-2′-methylenecytidine (DMDC)

✍ Scribed by Satoshi Shuto; Hirokazu Awano; Akihiro Fujii; Keiji Yamagami; Akira Matsuda


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
314 KB
Volume
6
Category
Article
ISSN
0960-894X

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ChemInform Abstract: Nucleosides and Nuc
✍ S. SHUTO; H. AWANO; A. FUJII; K. YAMAGAMI; A. MATSUDA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB

Nucleosides and Nucleotides. Part 155. Synthesis, Antitumor Effects, and Possible Enzymatic Activation Mechanism of 5'-Phosphatidyl-2'deoxy-2'-methylenecytidine (DMDC). -The title compounds (III) are synthesized using an enzyme-catalyzed transphosphatidylation. They show remarkable antileukemic and