Nucleosides and nucleotides. 150. Enzymatic synthesis of 5′-phosphatidyl derivatives of 1-(2-C-cyano-2-deoxy-β-d-arabino-pentofuranosyl)cytosine (CNDAC) and their notable antitumor effects in mice1

Antitumor activity and novel DNA-self-st

Antitumor activity and novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-C-cyano-2-deoxy-β-d-ARABINO-Pentofuranosyl) cytosine) and its N4-palmitoyl derivative (CS-682)

✍ Kenji Hanaoka; Masako Suzuki; Tomowo Kobayashi; Fumie Tanzawa; Kazuo Tanaka; Tak 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 221 KB

We have studied the antitumor activity and the novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-Ccyano-2-deoxy-␤-D-arabino-pentofuranosyl)cytosine) and its N 4 -palmitoyl derivative (CS-682). In vitro, CS-682 showed strong cytotoxicity against human tumor cells comparable with that of CNDAC;