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Synthesis and antiviral activity of 2-deoxy-1,5-anhydro-D-mannitol nucleosides containing a pyrimidine base moiety

✍ Scribed by María-Jesús Pérez-Pérez; Erik De Clercq; Piet Herdewijn

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 210 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00244-2

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✦ Synopsis

Nucleoside analogues containing a 2-deoxy-l,5-anhydro-D-mannitol and a pyrimidine base moiety were synthesized starting from D-glucose via a nucleophilie opening of an epoxide with the heterocyelic base and an inversion of configuration at the 3'-position. Study of the conformation of these molecules, that show some activity against herpesviruses fflSV, VZV, CMV) should increase our understanding of the structural requirements of hexitol nucleosides for antiviral activity.

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