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Nucleosides and Nucleotides. Part 13. Synthesis and spectral properties of 1- (3′-O-Phosphoryl-2′-deoxy-β -D-ribofuranosyl)-2(1H)-pyridone-(3′-5′)-1-(2′-deoxy-β-D-ribofuranosyl)-2 (1H)-pyridone

✍ Scribed by Nico Cerletti; Urs Séquin; Christoph Tamm; Werner Zürcher


Publisher
John Wiley and Sons
Year
1978
Tongue
German
Weight
444 KB
Volume
61
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

The dinucleoside phosphate Π~d~p__Π__~d~ (4) was synthesized from the monomers 1‐(5′‐O‐monomethoxytrityl ‐ 2′ ‐ deoxy ‐ β ‐ D ‐ ribofuranosyl) ‐ 2 (1 H) ‐ pyridone ((MeOTr) Π~d~, 2) and 1‐(5′‐O‐phosphoryl‐3′‐O‐acetyl‐2′‐deoxy‐β‐D‐ribofuranosyl)‐(1__H__)‐pyridone (p__Π__~d~(Ac), 3). Its 6.4% hyperchromicity and an analysis of the ^1^H‐NMR. spectra indicate that the conformation and the base‐base interactions in 4 are similar to those in natural pyrimidine dinucleoside phosphates.


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