Nucleosides and Nucleotides. Part 13. Synthesis and spectral properties of 1- (3′-O-Phosphoryl-2′-deoxy-β -D-ribofuranosyl)-2(1H)-pyridone-(3′-5′)-1-(2′-deoxy-β-D-ribofuranosyl)-2 (1H)-pyridone
✍ Scribed by Nico Cerletti; Urs Séquin; Christoph Tamm; Werner Zürcher
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- German
- Weight
- 444 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
The dinucleoside phosphate Π~d~p__Π__~d~ (4) was synthesized from the monomers 1‐(5′‐O‐monomethoxytrityl ‐ 2′ ‐ deoxy ‐ β ‐ D ‐ ribofuranosyl) ‐ 2 (1 H) ‐ pyridone ((MeOTr) Π~d~, 2) and 1‐(5′‐O‐phosphoryl‐3′‐O‐acetyl‐2′‐deoxy‐β‐D‐ribofuranosyl)‐(1__H__)‐pyridone (p__Π__~d~(Ac), 3). Its 6.4% hyperchromicity and an analysis of the ^1^H‐NMR. spectra indicate that the conformation and the base‐base interactions in 4 are similar to those in natural pyrimidine dinucleoside phosphates.
📜 SIMILAR VOLUMES
## Abstract Convergent syntheses of the 9‐(3‐X‐2,3‐dideoxy‐2‐fluoro‐__β__‐D‐ribofuranosyl)adenines **5** (X=N~3~) and **7** (X=NH~2~), as well as of their respective __α__‐anomers **6** and **8**, are described, using methyl 2‐azido‐5‐__O__‐benzoyl‐2,3‐dideoxy‐2‐fluoro‐__β__‐D‐ribofuranoside (**4**
## Base1 (17.11.92
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