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Novel Bronchodilators: Synthesis, Transamination Reactions, and Pharmacology of a Series of Pyrazino[2,3- c ][1,2,6]thiadiazine 2,2-Dioxides

✍ Scribed by Campillo, Nuria; García, Concepción; Goya, Pilar; Alkorta, Ibon; Páez, Juan A.

Book ID
120934362
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
169 KB
Volume
43
Category
Article
ISSN
0022-2623

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One pot alkoxylation at position 7 of 6-arylpyrazino [2,3c][1,2,6]thiadiazine 2,2-dioxides with NBS or NCS in the appropriate alcohol is described. Rationalization of the mechanism of the reaction, which does not proceed through the in-

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## GI ucosidationa of Q a m i n o -8 H -p ~o C 3 -c l [1,2,6llrhiadiazifie 2.2dioxide and its 6,7-dimetbyi-and 6,7-diphenyi derivatives via the "siiylation method" are described. The reaction favors N-1 substitution and the te~-U-acetylglucopyranosyl derivatives j, 6, and 7 as well as the free nud