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Pyrazino[2,3-c]-1,2,6-thiadiazine 2,2-dioxides. Synthesis of SO2 analogues of folic acid antagonists

✍ Scribed by Alkorta, Ibon ;Goya, Pilar ;Páez, Juan Antonio ;Pérez, Concepción

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
239 KB
Volume
1991
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

The synthesis of novel analogues of foric acid (FA) antagonists derived from the pyrazino[2,3‐c]‐1,2,6‐thiadiazine 2,2‐dioxide system incorporating the glutamic acid side chain at the 7‐position is described. No significant DHFR inhibition of cytotoxic activity has been found with these compounds.

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