Unconventional Alkoxylation of Pyrazino[2,3-c][1,2,6]thiadiazine 2,2-Dioxides Mediated by N-Halosuccinimides

✍ Scribed by Nuria Campillo; Juan A. Páez; Pilar Goya

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 74 KB
• Volume: 2002
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/1099-0690(200207)2002:13<2109::aid-ejoc2109>3.0.co;2-x

✦ Synopsis

One pot alkoxylation at position 7 of 6-arylpyrazino [2,3c][1,2,6]thiadiazine 2,2-dioxides with NBS or NCS in the appropriate alcohol is described. Rationalization of the mechanism of the reaction, which does not proceed through the in-