Pteridine analogues; synthesis and physico-chemical properties of 7-oxopyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides
✍ Scribed by Goya, Pilar ;Páez, Juan Antonio
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 380 KB
- Volume
- 1988
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Condensation of diarninothiadiazine l,l-dioxides 1 or 8 with 3tkcto acid cstcrs 2,6]thiadiazinc '.?-dioxides 2-4 and 9. Further chemical transformations yicld (7-substituted derivatives. Thc structures of the newly synthcsizcd compounds arc discussed on the basis of 'H-and I3C-NMR data, UV spcctra and pK, values.
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## Abstract The synthesis of novel analogues of foric acid (FA) antagonists derived from the pyrazino[2,3‐c]‐1,2,6‐thiadiazine 2,2‐dioxide system incorporating the glutamic acid side chain at the 7‐position is described. No significant DHFR inhibition of cytotoxic activity has been found with these
## GI ucosidationa of Q a m i n o -8 H -p ~o C 3 -c l [1,2,6llrhiadiazifie 2.2dioxide and its 6,7-dimetbyi-and 6,7-diphenyi derivatives via the "siiylation method" are described. The reaction favors N-1 substitution and the te~-U-acetylglucopyranosyl derivatives j, 6, and 7 as well as the free nud