Spectroscopic and photostability study of derivatives of pyrazino[2,3-c]-1,2,6-thiadiazine-2,2-dioxide
β Scribed by F. Catalina; J.L. Mateo; R. Sastre; A. Herrero; C. Ochoa; N.S. Allen
- Book ID
- 103993528
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 541 KB
- Volume
- 53
- Category
- Article
- ISSN
- 1010-6030
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## GI ucosidationa of Q a m i n o -8 H -p ~o C 3 -c l [1,2,6llrhiadiazifie 2.2dioxide and its 6,7-dimetbyi-and 6,7-diphenyi derivatives via the "siiylation method" are described. The reaction favors N-1 substitution and the te~-U-acetylglucopyranosyl derivatives j, 6, and 7 as well as the free nud
One pot alkoxylation at position 7 of 6-arylpyrazino [2,3c][1,2,6]thiadiazine 2,2-dioxides with NBS or NCS in the appropriate alcohol is described. Rationalization of the mechanism of the reaction, which does not proceed through the in-
## Abstract The synthesis of novel analogues of foric acid (FA) antagonists derived from the pyrazino[2,3βc]β1,2,6βthiadiazine 2,2βdioxide system incorporating the glutamic acid side chain at the 7βposition is described. No significant DHFR inhibition of cytotoxic activity has been found with these