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No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a Tunisian population

✍ Scribed by Afef Achouri Rassas, Sondess Hadj Fredj…

Book ID
120919143
Publisher
Springer
Year
2013
Tongue
English
Weight
166 KB
Volume
120
Category
Article
ISSN
1435-1463

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No association between the intronic pres
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## Wragg et al. [1996: Lancet 347:509-512] recorded an association between the intronbased presenilin 1 (PS1) genotype 1/1 and late-onset Alzheimer's disease (AD). This study was performed to determine if there is a similar association in the Chinese population. Ninety-one AD cases, 50 multiinfarc

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Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess