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No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease

โœ Scribed by Andrew B Singleton; Helen Lamb; Alan Leake; Ian G McKeith; Robert H Perry; Christopher M Morris

Book ID
117475743
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
62 KB
Volume
234
Category
Article
ISSN
0304-3940

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No association between the intronic pres
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## Wragg et al. [1996: Lancet 347:509-512] recorded an association between the intronbased presenilin 1 (PS1) genotype 1/1 and late-onset Alzheimer's disease (AD). This study was performed to determine if there is a similar association in the Chinese population. Ninety-one AD cases, 50 multiinfarc

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No association between the intronic presenilin-1 polymorphism and Alzheimer's disease in clinic and population-based samples
โœ Cai, Xingang; Stanton, Judith; Fallin, Dani; Hoyne, Jonathan; Duara, Ranjan; Gol ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 64 KB ๐Ÿ‘ 3 views

Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess