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No association of Presenilin-1 intronic polymorphism and Alzheimer's disease in Australia

✍ Scribed by K Taddei; D Yang; C Fisher; R Clarnette; J Hallmayer; R Barnetson; R Maller; W.S Brooks; S Whyte; G.A Nicholson; C.L Masters; G.A Broe; S.E Gandy; R.N Martins

Book ID
117476662
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
78 KB
Volume
246
Category
Article
ISSN
0304-3940

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Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess