## Wragg et al. [1996: Lancet 347:509-512] recorded an association between the intronbased presenilin 1 (PS1) genotype 1/1 and late-onset Alzheimer's disease (AD). This study was performed to determine if there is a similar association in the Chinese population. Ninety-one AD cases, 50 multiinfarc
No association between presenilin 1 (PS1) intronic polymorphism and sporadic Alzheimer's disease in Koreans
β Scribed by K. W. Kim; J. H. Jhoo; K. U. Lee; D. Y. Lee; J. H. Lee; J. Y. Youn; B. J. Lee; J. I. Woo
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 77 KB
- Volume
- 107
- Category
- Article
- ISSN
- 1435-1463
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Recent reports have shown an association between an intronic polymorphism of the presenilin-1 (PSEN1) gene and late-onset (age at onset > 65) familial and sporadic (no family history) Alzheimer disease (AD). The reported association was independent of the effect of the only previously identified gen
Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess
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