Recent reports have shown an association between an intronic polymorphism of the presenilin-1 (PSEN1) gene and late-onset (age at onset > 65) familial and sporadic (no family history) Alzheimer disease (AD). The reported association was independent of the effect of the only previously identified gen
✦ LIBER ✦
No association of the−48CT polymorphism of the presenilin 1 gene with Alzheimer disease in a late-onset sporadic population
✍ Scribed by L. Araria-Goumidi; J. B. Huguet; J. C. Lambert; B. Frigard; D. Cottel; P. Amouyel; M. C. Chartier-Harlin
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 40 KB
- Volume
- 109
- Category
- Article
- ISSN
- 1435-1463
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## 817 ated with increased risk for AD, at least in the Korean population. Nevertheless, it cannot be excluded that the association between IL-1A (-889) C/T polymorphism and AD observed in previous studies might be the result of linkage disequilibrium with a yet unidentified gene on chromosome 2.
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