No association between the intronic presenilin 1 polymorphism and Alzheimer's disease in the Chinese population

✍ Scribed by Wu, Xiaodong; Jiang, Sanduo; Lin, Sicui; Tang, Guomei; Feng, Guoying; Qian, Yiping; Wang, Dongxiang; Ren, Daming; Gu, Niufan

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 8 KB
• Volume: 88
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/(sici)1096-8628(19990205)88:1<1::aid-ajmg1>3.0.co;2-n

✦ Synopsis

Wragg et al. [1996:

Lancet 347:509-512] recorded an association between the intronbased presenilin 1 (PS1) genotype 1/1 and late-onset Alzheimer's disease (AD). This study was performed to determine if there is a similar association in the Chinese population. Ninety-one AD cases, 50 multiinfarct dementia (MID) patients, and 73 agematched normal controls were recruited. Genotyping of PS1 and apolipoprotein E (APOE) was performed by the methods of polymerase chain reaction and restriction fragment length polymorphism. In AD, MID, and normal controls PS1 allele 1 frequency was 0.6703, 0.5600, and 0.6301, respectively; PS1 allele 2 frequency was 0.3297, 0.4400, and 0.3699, respectively. No association was detected between these diseases and any PS1 allele or genotype. There was only a nearly significant negative association between MID and PS1 genotype 1/1 in the subgroup population bearing APOE allele E4 (odds ratio = 0.2753, P = 0.0776). Our results do not support the conclusion that the intronic PS1 polymorphism is associated with Alzheimer's disease. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:1-3, 1999.