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No association between serotonin transporter gene polymorphisms and personality traits

✍ Scribed by Gustavsson, J. Petter; N�then, Markus M.; J�nsson, Erik G.; Neidt, Helge; Forslund, Kaj; Rylander, Gunnar; Mattila-Evenden, Marja; Sedvall, G�ran C.; Propping, Peter; �sberg, Marie

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
51 KB
Volume
88
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(19990820)88:4<430::aid-ajmg23>3.0.co;2-1

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✦ Synopsis

Human family and twin studies have established considerable heritable components in personality traits as assessed by selfreport questionnaires. Recently, an association between a functional polymorphism in the upstream regulatory region of the serotonin transporter gene and neuroticismrelated personality traits was reported. Two different serotonin transporter polymorphisms including the previously associated variant were genotyped in two samples of healthy Swedish subjects (n = 127 and n = 178, respectively) assessed with the Karolinska Scales of Personality (KSP) inventory. No statistically significant association between serotonin transporter polymorphisms and any of the eight neuroticismrelated KSP scales was found. Thus, the previously reported association between serotonin transporter alleles and neuroticism-related personality traits could not be replicated in the present study.

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