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Genetic association study between ? 1-antichymotrypsin polymorphism and Alzheimer disease in Chinese Han population

✍ Scribed by Tang, Guomei; Jiang, Sanduo; Zhang, Mingyuan; Lin, Sicui; Qian, Yipin; Wu, Xiaodong; Wang, Dongxiang; Jin, Tongguan; Gu, Niufan

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 14 KB
Volume: 96
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(20000403)96:2<133::aid-ajmg1>3.0.co;2-y

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✦ Synopsis

We investigated a common signal peptide polymorphism in the ␣ 1-antichymotrypsin (ACT) gene in 125 sporadic Alzheimer disease (AD) patients and 141 healthy control subjects in Chinese Han population. We found no significant difference in the distribution of ACT polymorphism between AD cases and controls, and failed to detect any effects of ACT genotypes associated with AD. Thus, our data do not support the involvement of ACT polymorphism in the risk

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