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No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population

✍ Scribed by Metin Bagli; Andreas Papassotiropoulos; Sibylle G. Schwab; Frank Jessen; Marie Luise Rao; Wolfgang Maier; Reinhard Heun

Book ID
119470311
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
49 KB
Volume
167
Category
Article
ISSN
0022-510X

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Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess