N.C.A. labelling of aromatic compounds with 18F−
✍ Scribed by T. Guddat; W. Herdering; A. Knöchel; H. Salehi; O. Zwernemann
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 81 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2135
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📜 SIMILAR VOLUMES
## Abstract Fluorination of aromatic rings with no carrier added (n.c.a.) ^18^F‐fluoride was investigated using aryl triazenes and aryl iodides as substrates. Aryl triazenes give low yields of labeled under all conditions, and evidence was obtained to indicate that an inert solvent was unnecessary
To improve the accessibility of [18F]arylfluorides a method is presented using the decomposition of aromatic diazonium salts in the presence of [18F]fluoride. Several p-toluidyldiazonium salts have been synthesized and decomposed in the presence of fluoride. The most useful salt, ptoluidyldiazonium-
## Abstract The efficient and rapid nucleophilic exchange of fluorine by fluoride‐^18^F ion in aromatic rings is reported here utilizing rubidium‐^18^F‐fluoride in DMSO on model compounds. Specific activities in the 3 × 10^4^ Ci/mol region are readily achievable. Nucleophilic substitution is shown