A complex of the macrocyclic aminopolyether Kryptof ix@ 2.2.2. and potassium carbonate was used to synthesize [ 18F] -CH2BrF from dibromomethane. At the no-carrier-added level the nucleophilic 18F-for-Br exchange gives rise to a corrected radiochemical yield up to 62%.
✦ LIBER ✦
N.C.A. [18F]-labelling of aliphatic compounds in high yields via aminopolyether - supported nucleophilic substitution
✍ Scribed by Dirk Block; Bernd Klatte; Arndt Knöchel; Rainer Beckmann; Uwe Holm
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- French
- Weight
- 395 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-2135
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A macrocyclic aminopolyether (Kryptofix 2.2.2.) supported labelling method for the preparation of n.c.a. [17-FIfluoroheptadecanoic acid is described. The equimolar complex of potassium carbonate and the aminopolyether is used to provide nucleophilicity in a homogeneous solution of acetonitrile. Nuc