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Preparation of N.C.A. [18F]-CH2BrF via aminopolyether supported nucleophilic substitution

✍ Scribed by Heinrich Hubert Coenen; Marcello Colosimo; Manfred Schüller; Gerhard Stöcklin

Publisher: John Wiley and Sons
Year: 1986
Tongue: French
Weight: 295 KB
Volume: 23
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580230604

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✦ Synopsis

A complex of the macrocyclic aminopolyether Kryptof ix@ 2.2.2. and potassium carbonate was used to synthesize [ 18F] -CH2BrF from dibromomethane. At the no-carrier-added level the nucleophilic 18F-for-Br exchange gives rise to a corrected radiochemical yield up to 62%.

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Preparation of N.C.A. [17-18F]-fluorohep

Preparation of N.C.A. [17-18F]-fluoroheptadecanoic acid in high yields via aminopolyether supported, nucleophilic fluorination

✍ Heinrich Hubert Coenen; Manfred Schüller; Gerhard Stöcklin; Bernd Klatte; Arndt 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 French ⚖ 445 KB

A macrocyclic aminopolyether (Kryptofix 2.2.2.) supported labelling method for the preparation of n.c.a. [17-FIfluoroheptadecanoic acid is described. The equimolar complex of potassium carbonate and the aminopolyether is used to provide nucleophilicity in a homogeneous solution of acetonitrile. Nuc