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Development of a no-carrier-added method for 18F-labelling of aromatic compounds by fluorodediazonation

✍ Scribed by Arndt Knöchel; Olaf Zwernemann

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
467 KB
Volume
38
Category
Article
ISSN
0022-2135

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✦ Synopsis

To improve the accessibility of [18F]arylfluorides a method is presented using the decomposition of aromatic diazonium salts in the presence of [18F]fluoride. Several p-toluidyldiazonium salts have been synthesized and decomposed in the presence of fluoride. The most useful salt, ptoluidyldiazonium-2,4,6-~-isopropylbenxnesulfonate, has been used to investigate several parameters influencing the fluorination. Nocarrier-added labelling with [lgF]fluoride gave a radiochemical yield of 39% [l*F]p-fluorotoluene in a total synthesis time of 78 minutes.

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