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Aromatic fluorination with N.C.A. F-18 fluoride: A comparative study

✍ Scribed by M. S. Berridge; C. Crouzel; D. Comar

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
343 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Fluorination of aromatic rings with no carrier added (n.c.a.) ^18^F‐fluoride was investigated using aryl triazenes and aryl iodides as substrates. Aryl triazenes give low yields of labeled under all conditions, and evidence was obtained to indicate that an inert solvent was unnecessary for the reaction. Nucleophilic substitution of aromatic iodides in DMSO was found to be a superior method of fluorination yielding up to 70% incorporation of label. The scope and limitations of this new labeling reaction are reported.

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