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Labelling of fluorinated aromatics by isotopic exchange with [18F]fluoride

✍ Scribed by Fulvio Cacace; Maurizio Speranza; Alfred P. Wolf; Joanna S. Fowler

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
346 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The efficient and rapid nucleophilic exchange of fluorine by fluoride‐^18^F ion in aromatic rings is reported here utilizing rubidium‐^18^F‐fluoride in DMSO on model compounds. Specific activities in the 3 × 10^4^ Ci/mol region are readily achievable. Nucleophilic substitution is shown to be an attractive modality for fluorine‐18 labeling of aromatic compounds.

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